Semaglutide and tirzepatide have both shown benefits in studies involving women with PCOS, though much of the research has focused on their effects on weight and metabolic markers rather than PCOS specifically
[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial
BMC Pediatr 13:121 Parasuaraman G, Ayyasamy L, Aune D, Sen A, Nagarajan R, Rajkumar P et al (2023) The association between body mass index, abdominal fatness, and weight change and the risk of adult asthma: a systematic review and meta-analysis of cohort studies
They work through different mechanisms, they release growth hormone in different patterns, they have different dosing schedules, and they suit different patients
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11,107,194 The mechanisms which enable peripheral GLP-1 to induce satiety are not understood, but it is thought that GLP-1 binding to GLP-1R on neurons in the GIT, hepatoportal bed and CNS regulate this effect
